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New Horizons: Circadian Control of Metabolism Offers Novel Insight Into the Cause and Treatment of Metabolic Diseases
How the Body’s Internal Clock Controls Metabolism and Its Role in Metabolic Diseases and Treatments
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Abstract
Chronic circadian rhythm disruption may increase the risk for metabolic diseases.
- Almost every component of the metabolic regulatory system is influenced by circadian rhythms.
- Disruptions in circadian rhythms, such as those experienced by shift workers, are associated with heightened metabolic disease risk.
- Time-restricted eating (TRE), which limits caloric intake to a consistent 8 to 12-hour window, shows potential in preventing or reversing metabolic diseases in animal models.
- Understanding circadian rhythm can lead to new behavioral or pharmacological strategies for managing metabolic disorders.
- Research is ongoing to determine optimal timing for drug administration and to develop new drugs targeting the circadian clock for metabolic disease treatment.
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