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Circadian disruption in cancer hallmarks: Novel insight into the molecular mechanisms of tumorigenesis and cancer treatment
How Disrupted Body Clocks Relate to Key Cancer Traits and Their Molecular Causes
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Abstract
Circadian rhythms are linked to various cancer hallmarks, suggesting potential new treatment strategies.
- Circadian rhythms consist of 24-hour cycles driven by molecular clocks that regulate behavior and physiology.
- Disruption of these rhythms is associated with a range of pathologies, including cancer.
- Aberrant circadian control may lead to dedifferentiation of cells into progenitor-like states and the formation of cancer stem cells.
- Circadian rhythms may influence cellular senescence and the senescence-associated secretory phenotype.
- Interactions between circadian rhythms and epigenetics may impact the regulation of these rhythms.
- Disruptions in circadian rhythms could also affect microbiota communities, potentially contributing to cancer development.
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