Cancer letters

How Disrupted Body Clocks Relate to Key Cancer Traits and Their Molecular Causes

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Circadian rhythms are linked to various cancer hallmarks, suggesting potential new treatment strategies.

  • Circadian rhythms consist of 24-hour cycles driven by molecular clocks that regulate behavior and physiology.
  • Disruption of these rhythms is associated with a range of pathologies, including cancer.
  • Aberrant circadian control may lead to dedifferentiation of cells into progenitor-like states and the formation of cancer stem cells.
  • Circadian rhythms may influence cellular senescence and the senescence-associated secretory phenotype.
  • Interactions between circadian rhythms and epigenetics may impact the regulation of these rhythms.
  • Disruptions in circadian rhythms could also affect microbiota communities, potentially contributing to cancer development.

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Funding

Competing interests

Declaration of competing interest We claim the following statements: No conflict of interest exists in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.
PubMed

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