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Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses
Disrupting daily rhythms causes different changes in gut bacteria, fat-related molecules, and cell signaling in males and females
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Abstract
Females exhibited broader microbiota restructuring and decreased oxylipins in the jejunum after 10 days of constant light exposure.
- Constant light exposure is associated with changes in the fecal microbiome and short-chain fatty acids in both female and male mice.
- Males and females show pronounced increases in certain lipid levels in the brain, particularly in the hypothalamus of females.
- Muscle lipid changes were linked to muscle fiber type, with notable increases in various lipid classes in both sexes.
- Subcutaneous white adipose tissue in males displayed significantly decreased levels of oxylipins after constant light exposure.
- Females generally presented a more inflammatory profile in plasma compared to males.
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