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(Re)inventing the Circadian Feedback Loop
Renewing the Internal Body Clock Feedback Loop
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Abstract
Circadian clocks may involve simpler mechanisms than currently understood due to newly identified posttranslational oscillators.
- The traditional view of circadian clocks relies on feedback loops of transcription and translation.
- Recent findings show the presence of posttranslational circadian oscillators across various organisms.
- Canonical circadian clocks now include numerous proteins that operate in interconnected feedback loops.
- Self-sustained clock mechanisms could indicate that basic requirements for timekeeping are less complex than previously believed.
- Complex circadian timekeeping mechanisms might have developed from random interactions of separate feedback loops with limited timekeeping abilities.
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