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Circadian gene variants and breast cancer
Gene differences in the body’s internal clock and their link to breast cancer
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Abstract
Fifteen epidemiological studies suggest associations between specific circadian gene variants and breast cancer risk.
- Circadian rhythms play a crucial role in coordinating various physiological processes in organisms.
- Alterations in circadian genes may contribute to the multifactorial etiology of breast cancer.
- Exposure to light at night, such as through shift work, has been linked to circadian disruption and classified as a probable human carcinogen.
- Several candidate genes, including BMAL1, BMAL2, CLOCK, NPAS2, CRY1, CRY2, PER1, PER3, and TIMELESS, have been identified as potentially linked to breast cancer risk.
- Five of the fifteen studies specifically focused on the impact of shift work on breast cancer risk related to circadian gene polymorphisms.
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