Cancer letters

Gene differences in the body’s internal clock and their link to breast cancer

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Fifteen epidemiological studies suggest associations between specific circadian gene variants and breast cancer risk.

  • Circadian rhythms play a crucial role in coordinating various physiological processes in organisms.
  • Alterations in circadian genes may contribute to the multifactorial etiology of breast cancer.
  • Exposure to light at night, such as through shift work, has been linked to circadian disruption and classified as a probable human carcinogen.
  • Several candidate genes, including BMAL1, BMAL2, CLOCK, NPAS2, CRY1, CRY2, PER1, PER3, and TIMELESS, have been identified as potentially linked to breast cancer risk.
  • Five of the fifteen studies specifically focused on the impact of shift work on breast cancer risk related to circadian gene polymorphisms.

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