Time matters: circadian genetics and the molecular logic of human health and disease

Circadian misalignment may significantly influence disease risk and therapeutic response.

• The circadian clock regulates various physiological processes through a genetic timing system.
• Recent findings indicate that the circadian system is a complex network rather than a simple feedback loop.
• Genetic variations in core circadian genes can modify disease risk and progression.
• Understanding circadian mechanisms is crucial for advancing precision medicine.
• Future research should focus on the molecular clock's components and disease-specific models.

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