The circadian isoform landscape of mouse livers

Apr 16, 2026NAR genomics and bioinformatics

Daily patterns of different protein versions in mouse livers

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Abstract

Over 78 million full-length complementary DNA reads were generated from mouse liver RNA samples collected at 2-hour intervals.

  • Circadian processes in mouse livers are understood at the gene level but not at the level.
  • A total of 58,612 isoforms were identified and quantified from the transcriptome.
  • Out of these isoforms, 1,806 exhibited circadian oscillations.
  • Detailed analysis was conducted on the oscillation patterns of these isoforms, their coding sequences, and transcription start sites.
  • Resources have been compiled for other researchers to access this information.

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Key numbers

58 612
Identified
Total identified from mouse liver RNA samples
1 806
Circadian Oscillating
exhibiting circadian oscillations in expression
6.55 million
Average Reads per Time Point
Average number of reads generated for each time point in the study

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