How Sleep Problems and Body Clock Disruptions Relate to Thinking and Brain Function in People with Varying Insulin Resistance

Disrupted circadian rhythmicity and sleep disturbances were negatively associated with brain health across 27 studies.

• Circadian misalignment may increase the risk of cognitive decline and dementia in individuals with insulin resistance.
• Insulin sensitivity could be affected by sleep disturbances, impacting overall brain health.
• The effects of sleep duration and quality on cognitive outcomes remain unclear.
• Methodological differences and reliance on cross-sectional studies limit the ability to draw definitive conclusions.
• There is a need for future longitudinal and interventional studies that use objective measurements.

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