Proceedings of the National Academy of Sciences of the United States of AmericaFeb 6, 2010

The body clock gene takeout is controlled by Pdp1epsilon

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Updated Apr 2, 2026

Abstract

The Drosophila takeout gene is regulated by the transcription factor Pdp1epsilon.

Takeout RNA levels remain consistently high in Clk(JRK) mutants.
Pdp1epsilon serves as a regulator of takeout gene expression.
Reduced Pdp1epsilon levels lead to low takeout levels in Drosophila.
Increased Pdp1epsilon amounts result in elevated takeout levels.
Flies with altered Pdp1epsilon levels in the fat body exhibit courtship defects.

Simplified

The circadian clock controls many circadian outputs. Although a large number of transcripts are affected by the circadian oscillator, very little is known about their regulation and function. We show here that the Drosophila takeout gene, one of the output genes of the circadian oscillator, is regulated similarly to the circadian clock genes Clock (Clk) and cry. takeout RNA levels are at constant high levels in Clk(JRK) mutants. The circadian transcription factor PAR domain protein 1 (Pdp1epsilon) is a transcription factor that had previously been postulated to control clock output genes, particularly genes regulated similarly to Clk. In agreement with this, we show here that Pdp1epsilon is a regulator of takeout. Takeout levels are low in flies with reduced Pdp1epsilon and high in flies with increased amounts of Pdp1epsilon. Furthermore, flies with reduced or elevated Pdp1epsilon levels in the fat body display courtship defects, identifying Pdp1epsilon as an important transcriptional regulator in that tissue.

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The body clock gene takeout is controlled by Pdp1epsilon

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