The circadian output gene takeout is regulated by Pdp1ε

Feb 6, 2010Proceedings of the National Academy of Sciences of the United States of America

The body clock gene takeout is controlled by Pdp1epsilon

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Abstract

The Drosophila takeout gene is regulated by the transcription factor Pdp1epsilon.

  • Takeout RNA levels remain consistently high in Clk(JRK) mutants.
  • Pdp1epsilon serves as a regulator of takeout gene expression.
  • Reduced Pdp1epsilon levels lead to low takeout levels in Drosophila.
  • Increased Pdp1epsilon amounts result in elevated takeout levels.
  • Flies with altered Pdp1epsilon levels in the fat body exhibit courtship defects.

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