PDP1epsilon acts after the body clock to control daily behavior patterns

Reducing PDP1epsilon levels in clock cells by approximately 70% does not alter Clk mRNA cycling or circadian oscillator function.

• The circadian oscillator is regulated by feedback loops involving period/timeless and Clock proteins.
• VRI and PDP1epsilon proteins bind the same regulatory element, influencing Clk transcription levels.
• Constant low or high levels of PDP1epsilon disrupt locomotor activity rhythms while maintaining normal circadian oscillator function in brain neurons.
• PDP1epsilon is not essential for the activation of Clk, suggesting it may regulate the output of the circadian oscillator.

Simplified