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VRILLE Feeds Back to Control Circadian Transcription of Clock in the Drosophila Circadian Oscillator
VRILLE helps regulate daily activity of the Clock gene in fruit fly's internal clock
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Abstract
The gene vrille (vri) is identified as a key repressor of Clk transcription within the Drosophila circadian oscillator.
- The circadian oscillator in Drosophila consists of interlocked feedback loops involving period (per), timeless (tim), and Clock (Clk).
- CLK and CYCLE (CYC) activate the transcription of per and tim while repressing Clk transcription.
- VRI, a gene activated by CLK-CYC, encodes a repressor that targets Clk transcription.
- VRI also represses the blue light photoreceptor gene cryptochrome (cry), indicating its potential role in regulating other rhythmic genes.
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