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KAYAK-α Modulates Circadian Transcriptional Feedback Loops inDrosophilaPacemaker Neurons
KAYAK-α influences daily gene activity cycles in fruit fly internal clock neurons
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Abstract
KAY-α downregulation in circadian pacemaker neurons increases period length by 1.5 h.
- KAY-α is required for normal circadian behavior in Drosophila.
- Lower levels of KAY-α are associated with decreased expression of several circadian proteins.
- The strongest effects of KAY-α downregulation occur on the proteins CLK and the neuropeptide PIGMENT DISPERSING FACTOR.
- KAY-α can bind to VRI, inhibiting its interaction with the Clk promoter.
- KAY-α also represses CLK activity, suggesting a dual role in regulating circadian rhythms.
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