clockwork orange Encodes a Transcriptional Repressor Important for Circadian-Clock Amplitude in Drosophila

Jun 9, 2007Current biology : CB

Clockwork Orange controls gene activity important for daily rhythm strength in fruit flies

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Abstract

The bHLH-Orange repressor CG17100/CLOCKWORK ORANGE (CWO) is rhythmically expressed and reduced in Clk mutants.

  • CWO is activated by the CLOCK/CYCLE transcription factor in living organisms.
  • Mutations in cwo lead to reduced amplitude in molecular and behavioral rhythms.
  • cwo mutants exhibit lengthened periods in their circadian rhythms.
  • CWO may repress certain CLK target genes, influencing the overall rhythm.
  • CWO is proposed to function as a transcriptional and behavioral rhythm amplifier.

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