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Phosphorylation of the Transcription Activator CLOCK Regulates Progression through a ∼24-h Feedback Loop to Influence the Circadian Period in Drosophila
Phosphorylation of the CLOCK protein controls the 24-hour biological clock cycle in fruit flies
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Abstract
Eliminating phosphorylation at four specific CLK sites shortens the circadian period in Drosophila.
- Circadian clocks regulate daily rhythms in various organisms through transcriptional feedback loops.
- CLK-CYC initiates the transcription of the period and timeless genes, which in turn regulate CLK-CYC activity.
- Phosphorylation of CLK at specific sites is linked to its activity, influencing the timing of the feedback loop.
- Identifying eight CLK phosphorylation sites reveals their role in modulating behavioral and molecular rhythms.
- Loss of phosphorylation at certain sites can either accelerate the feedback loop or increase CLK activity.
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