PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock

Mar 6, 2019Proceedings of the National Academy of Sciences of the United States of America

Daily control of timeless gene message breakdown by PERIOD in the fruit fly's body clock

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Abstract

Down-regulation of the POP2 deadenylase alters behavioral rhythms in Drosophila.

  • Inhibition of POP2 increases levels of TIM protein and mRNA without affecting pre-mRNA.
  • The increase in TIM mRNA is linked to a lengthening of its poly(A) tail.
  • Effects of POP2 down-regulation on mRNA stability are dependent on the PER protein.
  • A mechanism is identified that regulates the oscillations of a core clock gene transcript.

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