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CLOCK stabilizes CYCLE to initiate clock function in Drosophila
CLOCK helps stabilize CYCLE to start the internal clock in fruit flies
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Abstract
CLK binds to and stabilizes CYC in cell culture and in nonclock cells in vivo.
- Circadian clocks operate in approximately 150 brain pacemaker neurons and various peripheral tissues.
- CLK-CYC heterodimers initiate transcription of genes that encode feedback repressors, PERIOD and TIMELESS.
- Ectopic clocks can be induced in nonclock cells by expressing CLK, although CYC expression remains limited to canonical clock cells.
- The blue light photoreceptor CRYPTOCHROME (CRY) is essential for light entrainment and clock function in peripheral tissues.
- Mechanisms governing circadian activator stability may be conserved across all eukaryotes.
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