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Circadian Activators Are Expressed Days before They Initiate Clock Function in Late Pacemaker Neurons fromDrosophila
Circadian activator proteins appear days before starting the body clock in fruit fly timing neurons
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Abstract
CLK-GFP is expressed in four of five clusters of late pacemaker neurons during the third instar larval stage.
- Circadian pacemaker neurons in Drosophila are categorized into early or late groups based on when they start expressing certain genes.
- Late pacemaker neurons begin to develop before the third instar larval stage, as indicated by the early expression of CLK-GFP.
- CLK-GFP is found only in postmitotic neurons during the third instar larval stage.
- CYC is also expressed exclusively in pacemaker neurons from third instar larval brains, similar to CLK.
- CLK-CYC expression does not trigger the activation of circadian genes in late pacemaker neurons at the third instar stage.
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