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Circadian regulation of cancer cell and tumor microenvironment crosstalk
Daily rhythms in communication between cancer cells and their surrounding environment
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Abstract
Circadian disruption is associated with tumorigenesis and tumor progression.
- Circadian rhythms influence a variety of physiological functions in living organisms.
- Disruption of these rhythms may affect cancer cell properties such as proliferation and DNA repair.
- Recent findings suggest that circadian clocks play an important role in the tumor microenvironment (TME).
- Cancer cell clock components regulate TME biology, while TME clock components may influence tumor growth and metastasis.
- Understanding the interaction between clock components in cancer cells and the TME could lead to novel therapeutic strategies.
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