The role of the body’s internal clock gene CLOCK in cancer

Abnormal expression of the CLOCK gene may lead to severe pathological effects, including cancer.

• CLOCK is a fundamental regulatory gene in the circadian rhythm.
• Dysfunctional CLOCK expression can disrupt its regulatory role in gene expression.
• The review discusses CLOCK's involvement in cancer development and progression.
• CLOCK may influence the tumor microenvironment and cancer cell metabolism.
• Abnormal CLOCK activity could be associated with drug resistance in cancer treatment.

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