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Circadian clocks: from stem cells to tissue homeostasis and regeneration
Body’s daily clocks in stem cells and their role in tissue maintenance and repair
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Abstract
The influences various physiological processes over a roughly 24-hour cycle.
- The circadian clock plays a role in regulating sleep, feeding, body temperature, and hormone levels.
- Molecular mechanisms involve the transcription factors BMAL1 and CLOCK, which control gene expression in a rhythmic manner.
- Disruptions to the circadian clock are linked to diseases, including sleep disorders, metabolic issues, and cancer.
- Circadian rhythms originate in stem cells and impact their maintenance and the physiology of differentiated cells and organs.
- Rhythmicity is associated with lineage commitment, tissue regeneration, and the aging process.
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