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The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell Signaling and Represses Tumor Initiation
The Body's Daily Rhythm Gene Bmal1 Controls Intestinal Stem Cell Signals and Helps Prevent Tumors
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Abstract
Loss of Bmal1 or circadian photoperiod increases tumor initiation in colorectal cancer models.
- The circadian clock gene Bmal1 is associated with the regulation of transcripts involved in intestinal regeneration and stem cell signaling.
- Tumors lacking Bmal1 exhibit low autonomous clock function and altered signaling pathways.
- Apc-disrupted tumors show elevated activity of Yes-associated protein 1, indicating changes in Hippo signaling, but reduced Wnt pathway activity.
- In intestinal organoids, the absence of Bmal1 leads to increased self-renewal dependent on Yes-associated protein 1.
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