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PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter
PI3K controls daily gene activity driven by BMAL1/CLOCK through the Dbp gene promoter
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Abstract
Pharmacological inhibition or knockdown of phosphatidylinositol 3-kinase (PI3K) blocked the upregulation of Dbp mRNA induced by serum shock in NIH 3T3 cells.
- PI3K inhibition significantly reduced the promoter activity of the Dbp gene.
- The recruitment of the BMAL1/CLOCK complex to the E-box in the Dbp promoter decreased with PI3K inhibition.
- Inhibition of PI3K interfered with the heterodimerization of BMAL1 and CLOCK.
- These findings suggest that PI3K signaling may modulate the transcriptional rhythm of the Dbp gene.
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