Biochemical and biophysical research communications

Mitomycin C changes daily rhythms of a clock gene by reducing stress hormone signals in mouse cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

After treatment with Mitomycin C (MMC), Bmal1 mRNA levels significantly decreased while Dbp, Per1, and Rev-erbα mRNA levels increased in mouse fibroblast cells.

  • The clock gene regulates the circadian rhythm of physiological functions.
  • MMC is commonly used in ocular surgeries like trabeculectomy.
  • MMC treatment altered clock gene expression in NIH3T3 fibroblast cells.
  • The Nr3c1 gene, which encodes the glucocorticoid receptor, was identified as a candidate for MMC-induced changes.
  • MMC suppressed the DEX-induced increase in Per1 mRNA levels.
  • These findings suggest a potential risk of circadian rhythm disorders at the ocular surface following MMC use.

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