Cell biochemistry and function

Increased levels of the body’s clock gene Bmal1 influence cell growth and a key cell signaling pathway in NIH-3T3 cells

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Bmal1 over-expression in NIH-3T3 cells resulted in increased cell proliferation rates.

  • Bmal1 is linked to circadian rhythms and may influence ageing features in mice.
  • Bmal1-/- mice displayed characteristics of premature ageing, including reduced bone mass.
  • Proliferation of bone marrow mesenchymal stem cells (BMSCs) and Bmal1 expression decreased with age.
  • A positive correlation may exist between Bmal1 protein levels and BMSC proliferation.
  • Increased expression of β-catenin, a key factor in the Wnt pathway, was observed following Bmal1 over-expression.

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