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Influence of the extracellular matrix on cell-intrinsic circadian clocks
How the surrounding cell environment affects internal biological clocks
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Abstract
Tissue stiffness may regulate circadian clocks in a cell-type-dependent manner.
- Circadian clocks help coordinate tissue health with daily rhythms.
- Disruptions in circadian clock mechanisms are associated with increased disease risk, particularly in aging, metabolic dysfunction, and cancer.
- The molecular components of circadian clocks control specific sets of rhythmic genes in different cell types.
- Changes in tissue structure and cellular environment throughout life may influence the functioning of circadian cycles.
- The extracellular matrix is linked to the differential regulation of circadian clocks across various tissues.
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