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The role of cryptochrome (CRY) in cancer: molecular mechanisms and clock-based therapeutic strategies
Cryptochrome's role in cancer: how it works and potential treatments based on the body’s internal clock
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Abstract
Circadian rhythms may influence the development of various cancers through the role of specific genes.
- Circadian rhythms cause physiological and behavioral processes to fluctuate roughly every 24 hours.
- Disruption of these rhythms in mammals is linked to diseases such as cancer, neurodegenerative disorders, and metabolic issues.
- Many genes exhibit daily oscillations, indicating their potential involvement in regulating gene expression.
- Cryptochromes (CRYs) are highlighted for their roles in the initiation and progression of different cancer types.
- There are connections between clock genes and the tumor microenvironment, suggesting complex interactions.
- Clock-based therapeutic strategies are being considered for their potential impact on cancer treatment.
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