M54 selectively stabilizes the circadian clock component of CRY1 and enhances the period of circadian rhythm at cellular level

Jun 6, 2025The Journal of biological chemistry

M54 specifically stabilizes the clock protein CRY1 and lengthens the daily rhythm in cells

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Abstract

M54 lengthens the period of the U2-OS circadian rhythm and decreases transcription of clock-controlled genes.

  • M54 binds specifically to CRY1, not CRY2.
  • Binding of M54 reduces the ubiquitination of CRY1, enhancing its stability.
  • The effect of M54 on circadian rhythm is concentration-dependent.
  • Findings suggest a potential role for M54 in therapeutic applications for circadian disorders linked to low CRY1 levels.

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