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The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1
The human CRY1 tail controls body clock timing by managing its interaction with the CLOCK:BMAL1 complex
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Abstract
The CRY1Δ11 mutant may lengthen circadian period, causing delayed sleep phase disorder (DSPD).
- Mutations in core clock genes can alter circadian periods.
- CRY1 functions as a repressor by inhibiting the activity of CLOCK:BMAL1.
- The CRY1 tail, particularly the region encoded by exon 11, influences the interaction between the PHR domain and CLOCK:BMAL1.
- The PHR-binding site in exon 11 is necessary to disrupt CRY1's interaction with CLOCK.
- Interactions between the PHR domain and the tail are preserved in the related protein CRY2 and are reduced when either CRY is bound to the corepressor PERIOD2.
- The autoregulatory role of the CRY1 tail and its interactions may be functionally conserved across different species.
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