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Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus
Cryptochrome 1 controls the body’s daily clock by interacting with the end part of BMAL1
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Abstract
CRY1 may regulate the circadian clock by competing with coactivators for binding to BMAL1, influencing the 24-hour cycle.
- CRY1 competes for binding with coactivators to the C-terminal transactivation domain of BMAL1.
- TAD mutations that change co-regulator affinities can alter the balance of activation and repression.
- These changes may affect the intrinsic circadian period or eliminate cycling.
- CRY1's role as a circadian repressor is linked to its ability to sequester the TAD from coactivators.
- Regulation of the BMAL1 TAD is suggested to be a critical mechanism for circadian timing.
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