Proceedings of the National Academy of Sciences of the United States of America

Circadian proteins CRY1 and CRY2 interact widely with gene regulators and influence gene activity

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

CRY1 and CRY2 serve as corepressors for many nuclear hormone receptors (NRs).

  • Circadian clocks influence transcriptional programs in mammals.
  • CRY1 and CRY2 bind to numerous genomic sites enriched for NR recognition motifs.
  • The interaction of CRY1/2 with NRs suggests a connection between circadian rhythms and metabolic regulation.
  • CRY1/2 may play a role in the daily modulation of drug metabolism.

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