Molecular process controlling the inactive phase of the mammal's daily biological clock

CRY-PER is associated with increased local concentrations of CK1δ at CLOCK-BMAL1-bound promoters.

• CRY-PER participates in the repression of CLOCK-BMAL1 activity through a displacement mechanism.
• CK1δ is recruited to the nucleus by CRY-PER, affecting CLOCK-BMAL1 function.
• An increased local concentration of CK1δ at promoters/enhancers may enhance the phosphorylation of CLOCK.
• Phosphorylation of CLOCK is linked to the dissociation of CLOCK-BMAL1 and CRY from the E-box.
• These observations provide clarity regarding the dynamic repressive phase of the circadian clock system.

Simplified