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Molecular mechanism of the repressive phase of the mammalian circadian clock
Molecular process controlling the inactive phase of the mammal's daily biological clock
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Abstract
CRY-PER is associated with increased local concentrations of CK1δ at CLOCK-BMAL1-bound promoters.
- CRY-PER participates in the repression of CLOCK-BMAL1 activity through a displacement mechanism.
- CK1δ is recruited to the nucleus by CRY-PER, affecting CLOCK-BMAL1 function.
- An increased local concentration of CK1δ at promoters/enhancers may enhance the phosphorylation of CLOCK.
- Phosphorylation of CLOCK is linked to the dissociation of CLOCK-BMAL1 and CRY from the E-box.
- These observations provide clarity regarding the dynamic repressive phase of the circadian clock system.
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