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Mammalian Period represses and de-represses transcription by displacing CLOCK–BMAL1 from promoters in a Cryptochrome-dependent manner
Mammalian Period controls gene activity by removing CLOCK-BMAL1 from DNA depending on Cryptochrome
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Abstract
PER protein may function as both a repressor and de-repressor of gene expression, depending on the context of the promoter.
- The primary circadian clock mechanism involves a transcription-translation feedback loop (TTFL).
- CLOCK-BMAL1 acts as a transcriptional activator while CRY and PER proteins serve as repressors.
- PER represses CLOCK-BMAL1 from binding to promoters in a manner that relies on CRY.
- The regulatory effects of PER vary according to the specific elements present in a gene's promoter.
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