We can’t show the full text here under this license. Use the link below to read it at the source.
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
Chemical study of the standard model for the mammal’s daily biological clock
AI simplified
Abstract
CLOCK:BMAL1 binds to an E-box sequence in DNA, while CRY binds stably to the CLOCK:BMAL1:E-box complex independently of PER.
- CRY and PER proteins interact with CLOCK and BMAL1 off DNA but have different binding behaviors with the CLOCK:BMAL1:E-box complex.
- PER interferes with CRY's binding to the CLOCK:BMAL1:E-box ternary complex.
- CRY may destabilize the CLOCK:BMAL1 heterodimer on DNA through a post-translational mechanism after binding.
- Findings indicate that while some aspects of the canonical circadian clock model are supported, key features may need revision.
AI simplified