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Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation
The CLOCK/BMAL1 circadian complex has two roles in controlling gene activity
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Abstract
The CLOCK/BMAL1 complex can suppress promoter activity through interaction with CRYPTOCHROME (CRY).
- CLOCK/BMAL1 is known to positively regulate E-box containing promoters.
- Interaction with CRY allows CLOCK/BMAL1 to also repress certain promoters.
- This dual function helps explain unexpected circadian gene expression patterns in Bmal1 null mice.
- The shift from activation to repression may enhance circadian gene expression control.
- CLOCK/BMAL1 can disrupt the regulation of genes by non-circadian transcription factors like N-MYC and ETS.
- Both repression and activation of gene transcription appear necessary for circadian responses to external stimuli, such as stress from anticancer treatment.
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