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Nuclear receptors rock around the clock
How nuclear receptors work in daily biological rhythms
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Abstract
impact various aspects of human physiology and are associated with multiple disease conditions.
- Disruption of normal circadian rhythms may contribute to conditions like depression, metabolic disorders, and cancer.
- The circadian clock is maintained by a molecular mechanism involving transcription factors such as CLOCK and BMAL, along with their co-repressors PER and CRY.
- (NRs) are hormone-sensitive transcriptional regulators that play roles in development, energy metabolism, and inflammation.
- Recent findings suggest that NRs not only are regulated by the circadian clock but also may regulate the clock itself.
- Nuclear receptors could be promising pharmacological targets for managing diseases linked to circadian rhythm disruption.
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