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REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology
Roles of REV-ERB nuclear receptors in daily metabolic and body rhythm regulation
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Abstract
Three new studies demonstrate that nuclear receptors of the Rev-Erb family influence the circadian oscillator and its metabolic functions.
- Disruption of circadian synchronization is associated with chronic diseases like metabolic syndrome and depression.
- Nuclear receptors of the Rev-Erb family play a role in regulating the circadian timing system.
- Specific agonists can modify the effects of these nuclear receptors on metabolic output.
- Manipulating the circadian oscillator with REV-ERB-specific agonists may help resynchronize metabolic pathways.
- This approach could offer a potential therapeutic strategy for diseases linked to circadian misalignment.
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