How synthetic REV-ERB activators affect daily rhythms and metabolism

Administration of synthetic REV-ERB ligands alters circadian behaviour and increases energy expenditure in mice.

• Synthetic REV-ERB agonists regulate the expression of core clock proteins that influence metabolic processes.
• Alterations in circadian behaviour and core clock gene expression were observed in the hypothalami of mice after treatment.
• Changes in the circadian expression of metabolic genes in the liver, skeletal muscle, and adipose tissue were noted.
• REV-ERB agonist treatment reduced fat mass in diet-induced obese mice, improving conditions like dyslipidaemia and hyperglycaemia.
• These findings suggest potential benefits of synthetic REV-ERB ligands for sleep disorders and metabolic diseases.

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