REV-ERB protein as a new target for treating disease

REV-ERB is a transcription factor linked to various physiological processes including circadian rhythm and metabolism.

• REV-ERB is implicated in the regulation of immune function and metabolism.
• Current understanding highlights the potential of REV-ERB as a drug target for treating several diseases.
• The modulation of REV-ERB can occur through both endogenous factors and synthetic ligands.
• There is a recognized need for higher quality synthetic ligands to enhance the validation of REV-ERB as a therapeutic target.

Simplified