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Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour
Drugs that affect the body's internal clock influence sleep patterns and emotions
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Abstract
Synthetic ligands targeting REV-ERBα and β regulate sleep architecture and emotional behavior in mice.
- REV-ERB agonists induce wakefulness while reducing REM and slow-wave sleep.
- Administration of REV-ERB agonists is associated with decreased anxiety-like behavior.
- REV-ERBβ-null mice exhibit increased anxiety-like behavior with no effect from REV-ERB agonists.
- These findings suggest that targeting REV-ERB may contribute to potential therapies for sleep disorders and anxiety.
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