REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009

REV-ERBβ deficiency is associated with altered gene expression and impaired maintenance of wakefulness.

• Circadian signaling influences various physiological and behavioral processes, including sleep and wakefulness.
• REV-ERBβ is implicated in maintaining wakefulness during the activity period.
• Mice lacking REV-ERBβ did not exhibit increased wakefulness when treated with a specific REV-ERB agonist.
• Gene expression related to sleep and wakefulness is altered in mice deficient in REV-ERBβ.

AI simplified