Pharmacological modulation and genetic deletion of REV-ERBα and REV-ERBβ regulates dendritic cell development

Both REV-ERBα and REV-ERBβ expression is upregulated during the differentiation of bone marrow derived dendritic cells.

• Dendritic cells play a crucial role in linking innate and adaptive immune responses.
• BMDCs lacking REV-ERBα and REV-ERBβ show increased maturation markers and proinflammatory cytokines.
• Treatment with a REV-ERB-specific agonist reduces the expression of maturation markers and proinflammatory cytokines.
• REV-ERBs may function as negative regulators in dendritic cell development and activation.
• Pharmacological targeting of REV-ERB activity could potentially adjust dendritic cell activation status.

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