The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

The core clock component PER2 is rhythmically bound at the promoters of nuclear receptor target genes in vivo.

• Mammalian circadian clocks rely on two interlocked feedback loops to generate daily rhythms.
• The core loop involves transcriptional repression by the Period (PER) and Cryptochrome (CRY) proteins.
• Nuclear receptors, influenced by PER2, regulate various metabolic and physiological pathways.
• PER2 interacts with nuclear receptors such as PPARalpha and REV-ERBalpha, acting as a coregulator of gene transcription.
• The interaction between the circadian oscillator and nuclear receptors may impact the expression of target genes related to metabolism.

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