Full text is available at the source.
Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age
Daily Body Clock Controlled by Polyamine Levels Through a Process That Weakens with Age
AI simplified
Abstract
Polyamine levels oscillate daily, influenced by both biological clocks and feeding patterns.
- Key enzymes in polyamine production are regulated by rhythmic interactions between the BMAL1:CLOCK complex and specific DNA elements.
- Circadian rhythms in cultured cells and animals are influenced by polyamines, which affect the interaction between core clock proteins PER2 and CRY1.
- Aged mice show a decline in polyamine levels that is linked to an extended circadian period.
- Dietary supplementation of polyamines can reverse the longer circadian period observed in older mice.
AI simplified