How the core clock protein BMAL1 adjusts daily rhythms to coordinate body functions from brain to organs

BMAL1-deficient mice exhibit the most drastic loss of circadian functions.

• Circadian clocks regulate physiological functions throughout the body by synchronizing various tissue clocks.
• The circadian adaptation system (CAS) relies on cell-autonomous molecular clocks that operate via a core feedback loop involving clock genes and proteins.
• Dysfunction in the CAS can lead to or worsen diseases.
• Numerous modifications of the circadian protein BMAL1, including phosphorylation and acetylation, influence the function of molecular clocks.
• These modifications interact to control physiological functions across the brain and peripheral tissues.

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