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The circadian clock regulates rhythmic erythropoietin expression in the murine kidney
The body’s internal clock controls daily cycles of red blood cell hormone in the mouse kidney
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Abstract
Wild-type mice showed a significant difference in kidney erythropoietin mRNA expression between circadian times 06 and 18.
- A higher number of erythropoietin-producing cells and increased circulating erythropoietin levels were observed at circadian time 18 in wild-type mice.
- These changes in erythropoietin expression were abolished in mice lacking cryptochromes 1 and 2 (Cry-null).
- Circadian erythropoietin expression is transcriptionally regulated by the CLOCK/BMAL1 activators and the CRY1/CRY2 repressors.
- The presence of Bmal1 was confirmed in erythropoietin-producing cells of the kidney.
- In Cry-null mice, a significantly reduced number of reticulocytes was found, while overall erythrocyte numbers and hematocrit levels remained unchanged.
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