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Circadian regulation of vascular function: Metabolism as a link from molecular mechanisms to clinical implications
Daily body clock control of blood vessel function: How metabolism connects molecular processes to health outcomes
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Abstract
Circadian rhythms are associated with the regulation of vascular physiology and metabolic processes.
- Cellular clocks in endothelial cells, smooth muscle cells, and fibroblasts dynamically influence vasodilation and inflammation.
- Crosstalk with metabolic pathways, including lipid turnover and oxidative stress responses, is evident and follows a circadian pattern.
- Disruption of circadian processes, particularly in shift workers or those with clock gene mutations, may raise the risk of hypertension and other vascular issues.
- Strategies such as chronotherapy and lifestyle modifications could align with circadian biology to improve vascular health.
- Future research should focus on understanding the timing and regulation of circadian and metabolic interactions for potential precision medicine applications.
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