Daily body clock control of blood vessel function: How metabolism connects molecular processes to health outcomes

Circadian rhythms are associated with the regulation of vascular physiology and metabolic processes.

• Cellular clocks in endothelial cells, smooth muscle cells, and fibroblasts dynamically influence vasodilation and inflammation.
• Crosstalk with metabolic pathways, including lipid turnover and oxidative stress responses, is evident and follows a circadian pattern.
• Disruption of circadian processes, particularly in shift workers or those with clock gene mutations, may raise the risk of hypertension and other vascular issues.
• Strategies such as chronotherapy and lifestyle modifications could align with circadian biology to improve vascular health.
• Future research should focus on understanding the timing and regulation of circadian and metabolic interactions for potential precision medicine applications.

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