Circadian rest-activity rhythm in chronic obstructive pulmonary disease

COPD patients showed higher rhythm fragmentation and lower relative amplitude compared to controls.

• COPD patients had an intradaily variability (IV) of 0.242, significantly higher than the 0.182 observed in controls.
• The average activity during the least active 5-hour period (L5) was greater in COPD patients at 36.849 compared to 19.888 in controls.
• Relative amplitude mean (RAm) in COPD patients was lower at 0.696 versus 0.833 in controls, indicating less synchronization to the light-dark cycle.
• These findings suggest altered circadian rhythms in individuals with COPD.

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