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Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Perspective and Therapeutic Potential
Circadian rhythm problems in neurodegenerative diseases may affect each other and could have treatment possibilities.
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Abstract
Circadian rhythm disruptions are recognized in age-related such as Alzheimer's, Parkinson's, and Huntington's disease.
- These disruptions may be causal factors that could manifest before clinical symptoms appear.
- A bidirectional relationship may exist where neurodegenerative processes and circadian dysfunction exacerbate one another.
- Core clock genes are involved in essential processes like redox balance, mitochondrial function, and neuroinflammation, which are often disrupted in these diseases.
- Current understanding of the exact mechanisms linking circadian disruptions to neurodegeneration remains unclear.
- Shared disruptions in across major neurodegenerative diseases have been observed, suggesting common underlying processes.
- The potential for circadian-oriented interventions to stabilize rhythms and mitigate disease progression is highlighted, though current evidence has limitations.
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