Association between circadian rhythms and neurodegenerative diseases

Circadian rhythm disruptions are observed in ageing adults, particularly in those with neurodegenerative diseases such as Alzheimer's and Parkinson's.

• Disruptions in 24-hour circadian rhythms are common in older adults, with greater severity in neurodegenerative diseases.
• The type and severity of neurodegenerative disease influence the specific manifestations of circadian rhythm disruptions.
• For some patients, circadian rhythm disruptions may occur before typical clinical symptoms of neurodegeneration appear.
• Preliminary evidence suggests that circadian rhythm disruptions could be a risk factor for developing Alzheimer's disease and related dementias, as well as Parkinson's disease.
• The relationship between circadian rhythms and neurodegeneration requires confirmation through large, longitudinal studies.
• Proposed mechanisms linking circadian rhythms to neurodegeneration include changes in protein balance and immune/inflammatory processes.

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