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Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease
Problems with daily body clocks and sleep in early Alzheimer's disease
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Abstract
Dysregulation of the circadian clock occurs during the asymptomatic stage of Alzheimer's disease.
- Circadian and sleep rhythm dysfunction is an early feature of many neurodegenerative diseases.
- Alzheimer's disease is associated with cognitive and psychiatric disturbances.
- It is unclear if sleep and circadian rhythm disruptions contribute to Alzheimer's or are a consequence of the disease.
- Evidence suggests a complex, self-reinforcing relationship between these disruptions and neurodegeneration.
- Restoring sleep and circadian rhythms in preclinical Alzheimer's may offer an opportunity for early intervention.
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