Acta physiologica (Oxford, England)

Problems with daily body clocks and sleep in early Alzheimer's disease

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Abstract

Dysregulation of the circadian clock occurs during the asymptomatic stage of Alzheimer's disease.

  • Circadian and sleep rhythm dysfunction is an early feature of many neurodegenerative diseases.
  • Alzheimer's disease is associated with cognitive and psychiatric disturbances.
  • It is unclear if sleep and circadian rhythm disruptions contribute to Alzheimer's or are a consequence of the disease.
  • Evidence suggests a complex, self-reinforcing relationship between these disruptions and neurodegeneration.
  • Restoring sleep and circadian rhythms in preclinical Alzheimer's may offer an opportunity for early intervention.

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